Rat FK506 binding protein 1A, 12kDa ELISA Kit | FKBP1A elisa kit
Rat Peptidyl-prolyl cis-trans isomerase FKBP1A, FKBP1A ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.
Protein type: EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; cytoplasm; nerve terminal; Z disc; cytosol
Molecular Function: protein binding; signal transducer activity; enzyme binding; protein homodimerization activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; activin binding; macrolide binding; calcium channel inhibitor activity; Hsp70 protein binding; SMAD binding; transforming growth factor beta receptor binding
Biological Process: heart morphogenesis; protein maturation via protein folding; protein peptidyl-prolyl isomerization; T cell activation; positive regulation of protein binding; protein folding; response to caffeine; T cell proliferation; regulation of protein localization; muscle contraction; negative regulation of protein amino acid phosphorylation; negative regulation of release of sequestered calcium ion into cytosol; transforming growth factor beta receptor signaling pathway; fibril organization and biogenesis; ventricular cardiac muscle morphogenesis; protein refolding; response to iron ion; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; regulation of activin receptor signaling pathway; SMAD protein complex assembly; negative regulation of protein phosphatase type 2B activity; 'de novo' protein folding; positive regulation of protein ubiquitination; release of sequestered calcium ion into cytosol
Research Articles on FKBP1A
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Product Notes
The Rat FKBP1A fkbp1a (Catalog #AAA9326780) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326780 ELISA Kit recognizes Rat FKBP1A. It is sometimes possible for the material contained within the vial of "FK506 binding protein 1A, 12kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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