Fish Restin (RSN) ELISA Kit | RSN elisa kit

Fish Restin (RSN) ELISA Kit

Gene Names

CLIP1; RSN; CLIP; CYLN1; CLIP170; CLIP-170

Reactivity

Fish

Synonyms

Restin (RSN); Fish Restin (RSN) ELISA Kit; RSN elisa kit

Ordering

Reactivity

Fish

Sequence Length

Preparation and Storage

Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #

45685671

NCBI GeneID

6249

Molecular Weight

156,781 Da

NCBI Official Full Name

restin isoform b, partial

NCBI Official Synonym Full Names

CAP-Gly domain containing linker protein 1

NCBI Official Symbol

CLIP1

NCBI Official Synonym Symbols

RSN; CLIP; CYLN1; CLIP170; CLIP-170

NCBI Protein Information

CAP-Gly domain-containing linker protein 1

UniProt Protein Name

CAP-Gly domain-containing linker protein 1

UniProt Gene Name

CLIP1

UniProt Synonym Gene Names

CYLN1; RSN; CLIP-170

NCBI Description

The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

Restin: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: centrosome; cytoplasmic microtubule; cytoplasmic vesicle membrane; cytosol; endosome; intermediate filament; kinetochore; macropinosome; microtubule; microtubule cytoskeleton; nuclear envelope; ruffle

Molecular Function: metal ion binding; microtubule binding; microtubule plus-end binding; protein binding; protein homodimerization activity; tubulin binding; zinc ion binding

Biological Process: microtubule bundle formation; mitotic cell cycle; positive regulation of microtubule polymerization; sister chromatid cohesion

Research Articles on RSN

1. single-molecule fluorescence microscopy showed that the microtubule plus-end-associated protein CLIP-170 binds tightly to formins to accelerate actin filament elongation.

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Product Notes

The Fish RSN clip1 (Catalog #AAA9903461) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9903461 ELISA Kit recognizes Fish RSN. It is sometimes possible for the material contained within the vial of "Restin (RSN), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Fish Restin (RSN) ELISA Kit | RSN elisa kit