FGR recombinant protein

FGR protein

Cat. Num. AAA5304538

• Gene Names: Fgr; p55-Fgr
• Purity: FGR protein was purified using a a proprietary chromatographic technique.
• Synonyms: FGR; FGR protein; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog protein; FGR recombinant protein

• Host: Human
• Purity/Purification: FGR protein was purified using a a proprietary chromatographic technique.
• Form/Format: Supplied in a storage buffer consisting of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF and 25% glycerol
• Sequence Length: 517

• Protein Type: Recombinant
• Biological Significance: Fgr is a protooncogene that is a unique member of the tyrosine kinase gene family. It is localized to the distal portion of the short arm of human chromosome 1 at p36.1-36.2 by in situ hybridization. Certain lymphomas express fgr-related messenger RNA. This transcript is detected in Burkitt's lymphoma cell lines naturally infected with Epstein-Barr virus, but not in EBV-negative Burkitt's lymphoma cells. Normal umbilical cord or peripheral blood lymphocyte lines established in vitro by EBV infection also contain detectable c-fgr mRNA. Moreover, a 50-fold increase of the steady-state c-fgr mRNA concentration is observed when uninfected Burkitt's lymphoma cell lines are deliberately infected with EBV demonstrating the induction of a proto-oncogene in response to infection by a DNA tumour virus.
• Expression System: Sf-9 insect cells
• Preparation and Storage: Store at -80 degree C

Related Product Information for FGR recombinant protein

Purified recombinant Human FGR protein

Product Categories/Family for FGR recombinant protein

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 56146
• NCBI GeneID: 79113
• UniProt Accession #: Q63206; Q6P6U0
• Molecular Weight: 86 kDa
• NCBI Official Full Name: FGR
• NCBI Official Synonym Full Names: FGR proto-oncogene, Src family tyrosine kinase
• NCBI Official Symbol: Fgr
• NCBI Official Synonym Symbols: p55-Fgr
• NCBI Protein Information: tyrosine-protein kinase Fgr
• UniProt Protein Name: Tyrosine-protein kinase Fgr
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: Fgr
• UniProt Entry Name: FGR_RAT

NCBI Description

phosphorylates phospholipase D2 (PLD2); plays a role in mast cell activation [RGD, Feb 2006]

Uniprot Description

FGR: a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers.

Protein type: Protein kinase, tyrosine (non-receptor); Oncoprotein; Kinase, protein; Protein kinase, TK; Mitochondrial; EC 2.7.10.2; TK group; Src family

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; mitochondrial inner membrane; plasma membrane; mitochondrial intermembrane space; cytosol; actin cytoskeleton

Molecular Function: protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; ATP binding; receptor binding

Biological Process: integrin-mediated signaling pathway; cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of mast cell degranulation; regulation of phagocytosis; regulation of cell proliferation; regulation of innate immune response; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; defense response to Gram-positive bacterium; innate immune response; cell differentiation; regulation of protein kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; positive regulation of cytokine secretion