Fibrinogen beta chain (FGB) Recombinant Protein | FGB recombinant protein
Recombinant Bovine Fibrinogen beta chain (FGB)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Fibrinogen beta chain (FGB); Recombinant Bovine Fibrinogen beta chain (FGB); FGB recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
22-468, Full length protein
Sequence
GHRPYDKKKEEAPSLRPVPPPISGGGYRARPATATVGQKKVERKPPDADGCLHADPDLGVLCPTGCKLQDTLVRQERPIRKSIEDLRNTVDSVSRTSSSTFQYITLLKNMWKGRQNQVQDNENVVNEYSSHLEKHQLYIDETVKNNIPTKLRVLRSILENLRSKIQKLESDVSTQMEYCRTPCTVTCNIPVVSGKECEKIIRNEGETSEMYLIQPEDSSKPYRVYCDMKTEKGGWTVIQNRQDGSVDFGRKWDPYKQGFGNIATNAEGKKYCGVPGEYWLGNDRISQLTNMGPTKLLIEMEDWKGDKVTALYEGFTVQNEANKYQLSVSKYKGTAGNALIEGASQLVGENRTMTIHNSMFFSTYDRDNDGWKTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGAYTWDMAKHGTDDGVVWMNWQGSWYSMKKMSMKIRPYFPEQ
Sequence Length
447
Species
Bovine
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for FGB recombinant protein
This protein is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
53,340 Da
NCBI Official Full Name
Fibrinogen beta chain
NCBI Official Synonym Full Names
fibrinogen beta chain
NCBI Official Symbol
FGB
NCBI Protein Information
fibrinogen beta chain
UniProt Protein Name
Fibrinogen beta chain
Protein Family
UniProt Gene Name
FGB
Uniprot Description
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Research Articles on FGB
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Product Notes
The FGB fgb (Catalog #AAA967422) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-468, Full length protein. The amino acid sequence is listed below: GHRPYDKKKE EAPSLRPVPP PISGGGYRAR PATATVGQKK VERKPPDADG CLHADPDLGV LCPTGCKLQD TLVRQERPIR KSIEDLRNTV DSVSRTSSST FQYITLLKNM WKGRQNQVQD NENVVNEYSS HLEKHQLYID ETVKNNIPTK LRVLRSILEN LRSKIQKLES DVSTQMEYCR TPCTVTCNIP VVSGKECEKI IRNEGETSEM YLIQPEDSSK PYRVYCDMKT EKGGWTVIQN RQDGSVDFGR KWDPYKQGFG NIATNAEGKK YCGVPGEYWL GNDRISQLTN MGPTKLLIEM EDWKGDKVTA LYEGFTVQNE ANKYQLSVSK YKGTAGNALI EGASQLVGEN RTMTIHNSMF FSTYDRDNDG WKTTDPRKQC SKEDGGGWWY NRCHAANPNG RYYWGGAYTW DMAKHGTDDG VVWMNWQGSW YSMKKMSMKI RPYFPEQ. It is sometimes possible for the material contained within the vial of "Fibrinogen beta chain (FGB), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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