Mouse Fermitin family homolog 3 ELISA Kit | Fermt3 elisa kit
Mouse Fermitin family homolog 3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
kindlin-3: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3); also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes. Belongs to the kindlin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component: membrane; podosome
Molecular Function: integrin binding; protein binding
Biological Process: integrin activation; integrin-mediated signaling pathway; leukocyte adhesion; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin
Research Articles on Fermt3
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Product Notes
The Mouse Fermt3 fermt3 (Catalog #AAA9427294) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9427294 ELISA Kit recognizes Mouse Fermt3. It is sometimes possible for the material contained within the vial of "Fermitin family homolog 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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