WB (Western Blot)
(Anti-GRB7 antibody, AAA45711, All Western blottingAll lanes: Anti-GRB7(AAA45711) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: A549 Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD)
Rabbit GRB7 Polyclonal Antibody | anti-GRB7 antibody
Anti-GRB7 antibody
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
GRB7, Antibody; Anti-GRB7 antibody; Growth factor receptor-bound protein 7; growth factor receptor-bound protein 7; B47 antibody; Epidermal growth factor receptor GRB 7 antibody; Epidermal growth factor receptor GRB-7 antibody; GRB7 adapter protein antibody; GRB7 antibody; GRB7_HUMAN antibody; Growth factor receptor bound protein 7 antibody; Growth factor receptor-bound protein 7 antibody; OTTHUMP00000164349 antibody; OTTHUMP00000164350 antibody; OTTHUMP00000164351 antibody; OTTHUMP00000164352 antibody; anti-GRB7 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
532
Applicable Applications for anti-GRB7 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human GRB7 (124-141aa ARHVCEMLVQRAHALSDE), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Anti-GRB7 antibody, AAA45711, All Western blottingAll lanes: Anti-GRB7(AAA45711) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: A549 Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD)
WB (Western Blot)
(Anti-GRB7 antibody, AAA45711, All Western blottingAll lanes: Anti-GRB7(AAA45711) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: A549 Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD)
IHC (Immunohistochemistry)
(Anti-GRB7 antibody, AAA45711, IHC(P)IHC(P): Human Oesophagus Squama Cancer Tissue)
IHC (Immunohistochemistry)
(Anti-GRB7 antibody, AAA45711, IHC(P)IHC(P): Human Oesophagus Squama Cancer Tissue)
Related Product Information for anti-GRB7 antibody
Description: Rabbit IgG polyclonal antibody for Growth factor receptor-bound protein 7(GRB7) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 thought to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
Background: GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 thought to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
55,920 Da
NCBI Official Full Name
Growth factor receptor-bound protein 7
NCBI Official Synonym Full Names
growth factor receptor-bound protein 7
NCBI Official Symbol
GRB7
NCBI Protein Information
growth factor receptor-bound protein 7; B47; GRB7 adapter protein; epidermal growth factor receptor GRB-7
UniProt Protein Name
Growth factor receptor-bound protein 7
UniProt Gene Name
GRB7
UniProt Entry Name
GRB7_HUMAN
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Product Notes
The GRB7 grb7 (Catalog #AAA45711) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GRB7 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GRB7 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the GRB7 grb7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRB7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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