Fc gamma RI/FCGR1A/CD64 Recombinant Protein | FCGR1A recombinant protein

Recombinant Human Fc gamma RI/FCGR1A/CD64 Protein (C-His)

Cat. Num. AAA2557264

• Gene Names: FCGR1A; CD64; FCRI; CD64A; IGFR1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Fc gamma RI/FCGR1A/CD64; Recombinant Human Fc gamma RI/FCGR1A/CD64 Protein (C-His); Ig gamma-4 chain C region; IgG4 Fc; FCGR1A recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH7.4.
• Sequence: Gln16-Pro288
• Sequence Length: 374

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for FCGR1A recombinant protein

Protein Construction: Recombinant Human FCGR1A is produced by our mammalian expression system and the target gene encoding Gln16-Pro288 is expressed with a 6His tag at the C-terminus.

Background: CD64 (FcgammaRI), one of the Fc receptors for IgG, is a membrane glycoprotein that mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. CD64 is also structurally distinct, containing an extracellular Ig-interactive region of three Ig-like domains in contrast to the two domains of the low affinity receptors FcgammaRII and FcgammaRIII. It is normally expressed on the surfaces of monocytes and macrophages.

NCBI and Uniprot Product Information

• NCBI GI #: 50403717
• NCBI GeneID: 2209
• UniProt Accession #: P12314
• Molecular Weight: Molecular Mass: 31.7kDa; Actual Protein Molecular Mass: 50-70kDa
• NCBI Official Full Name: High affinity immunoglobulin gamma Fc receptor I
• NCBI Official Synonym Full Names: Fc fragment of IgG receptor Ia
• NCBI Official Symbol: FCGR1A
• NCBI Official Synonym Symbols: CD64; FCRI; CD64A; IGFR1
• NCBI Protein Information: high affinity immunoglobulin gamma Fc receptor I
• UniProt Protein Name: High affinity immunoglobulin gamma Fc receptor I
• UniProt Gene Name: FCGR1A
• UniProt Synonym Gene Names: FCG1; FCGR1; IGFR1; IgG Fc receptor I; FcRI; FcgammaRIa
• UniProt Entry Name: FCGR1_HUMAN

NCBI Description

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: early endosome membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; IgG binding; receptor signaling protein activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; signal transduction; phagocytosis, engulfment