F-box only protein 18 (Fbxo18) Recombinant Protein | Fbxo18 recombinant protein

Recombinant Mouse F-box only protein 18 (Fbxo18) , partial

• Gene Names: Fbxo18; Fbh1; Fbx18; AU015756
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: F-box only protein 18 (Fbxo18); Recombinant Mouse F-box only protein 18 (Fbxo18); partial; Fbxo18 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 821

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Fbxo18 recombinant protein

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 21703350
• NCBI GeneID: 50755
• NCBI Accession #: NP_056607.1
• NCBI GenBank Nucleotide #: NM_015792.2
• UniProt Accession #: Q8K2I9; Q8C444; Q99KS0; Q9CTC6; Q9QZG7
• Molecular Weight: 92,965 Da
• NCBI Official Full Name: F-box DNA helicase 1 isoform 1
• NCBI Official Synonym Full Names: F-box protein 18
• NCBI Official Symbol: Fbxo18
• NCBI Official Synonym Symbols: Fbh1; Fbx18; AU015756
• NCBI Protein Information: F-box DNA helicase 1
• UniProt Protein Name: F-box DNA helicase 1
• Protein Family: F-box DNA helicase
• UniProt Gene Name: Fbxo18

Uniprot Description

3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location ().