E3 ubiquitin-protein ligase FANCL (Fancl) Recombinant Protein | Fancl recombinant protein
Recombinant Mouse E3 ubiquitin-protein ligase FANCL (Fancl)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Description
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
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Product Notes
The Fancl fancl (Catalog #AAA1409949) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-375, full length protein. The amino acid sequence is listed below: DEAEASLLRH FPLLLPQNRE KTVYEGFISA QGSDFHLRIV LPKDLQLKKA RLLCSLQLKN ILNEYHQVVQ QRMKHSPDLM SFMMELKMIL EVALKNKQEL CVQPPSCSFC KDLLTEIGAI GWDKLACVES SFSTIKLKAD DASGRKHLIT VKLKAKYPVE PPDCVVDFPV PFSVSWTPQS SLVDVYSQFL VALETLKVFW DVMDEIDEKT WVLEPEKPPR SATARRIALG KNVSIAIEVD PRHPTMLPEF CFLGADHVTK PLGMKLSGSI HLWDPENSLL QNLKDVLEID FPARSILEES DFSMDCGICY ARHLNGAIPD QVCNNPQCGQ PFHEICLYEW LRGLSTSRQS FNVFFGDCPY CSKPITLKMS GRKP. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase FANCL (Fancl), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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