FAM3C recombinant protein

FAM3C Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121934

• Gene Names: FAM3C; ILEI; GS3786
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FAM3C; FAM3C Protein; Human; Recombinant (His Tag); Human FAM3C/ILEI Protein (His Tag); GS3786 Protein; ILEI Protein; family with sequence similarity 3; member C; FAM3C recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asp227

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gln 25
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human FAM3C (NP_055703.1)(Met1-Asp227) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FAM3C recombinant protein

Background: FAM3C, also known as ILEI, is a member of theFAM3 family. It can be detected in resent in most secretory epithelia. FAM3C may be involved in retinal laminar formation. It promotes epithelial to mesenchymal transition. A change in expression of FAM3C has been noted in pancreatic cancer-derived cells. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.

References

Zhu Y. et al., 2002, Genomics. 80 (2): 144-50. Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903. Qua©ma©ner-Redon S. et al., 2003, Nature. 424 (6945): 157-64.

NCBI and Uniprot Product Information

• NCBI GI #: 7661714
• NCBI GeneID: 10447
• NCBI Accession #: NP_055703.1
• NCBI GenBank Nucleotide #: NM_014888.2
• UniProt Accession #: Q92520; A6NDN2; A8K3R7
• Molecular Weight: 24,680 Da
• NCBI Official Full Name: protein FAM3C
• NCBI Official Synonym Full Names: family with sequence similarity 3, member C
• NCBI Official Symbol: FAM3C
• NCBI Official Synonym Symbols: ILEI; GS3786
• NCBI Protein Information: protein FAM3C; interleukin-like EMT inducer; predicted osteoblast protein; interleukin-like epithelial-mesenchymal transition inducer
• UniProt Protein Name: Protein FAM3C
• Protein Family: Protein
• UniProt Gene Name: FAM3C
• UniProt Synonym Gene Names: ILEI
• UniProt Entry Name: FAM3C_HUMAN

NCBI Description

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

Uniprot Description

FAM3C: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. Belongs to the FAM3 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: Golgi apparatus; cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: cytokine activity

Biological Process: multicellular organismal development