Human endogenous retroviral family W, env (C7) , member 1 ELISA Kit | ERVWE1 elisa kit
Human HERV-W_7q21.2 provirus ancestral Env polyprotein, ERVWE1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: plasma membrane; integral to membrane; viral envelope
Biological Process: anatomical structure morphogenesis; syncytium formation
Research Articles on ERVWE1
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Product Notes
The Human ERVWE1 ervw-1 (Catalog #AAA9318236) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318236 ELISA Kit recognizes Human ERVWE1. It is sometimes possible for the material contained within the vial of "endogenous retroviral family W, env (C7) , member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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