Endoplasmic Reticulum Protein 44 Recombinant Protein | ERP44 recombinant protein

Recombinant Endoplasmic Reticulum Protein 44 (ERP44)

Cat. Num. AAA2123459

• Gene Names: ERP44; PDIA10; TXNDC4
• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: Endoplasmic Reticulum Protein 44; Recombinant Endoplasmic Reticulum Protein 44 (ERP44); TXNDC4; PDIA10; Thioredoxin Domain Containing 4; Protein Disulfide Isomerase Family A; Member 10; ERP44 recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Met1~Gln286
• Sequence Length: 406

• Applicable Applications for ERP44 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His and GST Tag
• Subcellular Location: Endoplasmic reticulum lumen
• Isoelectric Point: 4.8
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for ERP44 recombinant protein

Neuro science

NCBI and Uniprot Product Information

• NCBI GI #: 31077035
• NCBI GeneID: 23071
• UniProt Accession #: Q9BS26
• Molecular Weight: Predicted Molecular Mass: 63.3kDa; Accurate Molecular Mass: 63kDa
• NCBI Official Full Name: Endoplasmic reticulum resident protein 44
• NCBI Official Synonym Full Names: endoplasmic reticulum protein 44
• NCBI Official Symbol: ERP44
• NCBI Official Synonym Symbols: PDIA10; TXNDC4
• NCBI Protein Information: endoplasmic reticulum resident protein 44
• UniProt Protein Name: Endoplasmic reticulum resident protein 44
• Protein Family: Endoplasmic reticulum resident protein
• UniProt Gene Name: ERP44
• UniProt Synonym Gene Names: KIAA0573; TXNDC4; ER protein 44; ERp44
• UniProt Entry Name: ERP44_HUMAN

NCBI Description

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

Uniprot Description

ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress.

Protein type: Secreted, signal peptide; Endoplasmic reticulum; Secreted; Isomerase

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein