Human excision repair cross-complementing rodent repair deficiency, complementation group 4 ELISA Kit | ERCC4 elisa kit
Human DNA repair endonuclease XPF, ERCC4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
Uniprot Description
ERCC4: Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F); also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS). This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly. Belongs to the XPF family.
Protein type: EC 3.1.-.-; Deoxyribonuclease; DNA repair, damage
Chromosomal Location of Human Ortholog: 16p13.12
Cellular Component: nucleoplasm; nucleotide-excision repair complex; chromosome, telomeric region; transcription factor TFIID complex; nuclear chromosome, telomeric region; nucleus
Molecular Function: protein C-terminus binding; protein binding; structure-specific DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; damaged DNA binding; protein N-terminus binding; single-stranded DNA binding; endodeoxyribonuclease activity
Biological Process: nucleotide-excision repair, DNA incision; DNA repair; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; nucleotide-excision repair, DNA incision, 3'-to lesion; negative regulation of telomere maintenance; UV protection; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; resolution of meiotic joint molecules as recombinants; nucleotide-excision repair, DNA damage removal; telomere maintenance; nucleotide-excision repair, DNA incision, 5'-to lesion; response to UV
Disease: Fanconi Anemia, Complementation Group Q; Xeroderma Pigmentosum, Complementation Group F; Xfe Progeroid Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Research Articles on ERCC4
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Product Notes
The Human ERCC4 ercc4 (Catalog #AAA9328610) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328610 ELISA Kit recognizes Human ERCC4. It is sometimes possible for the material contained within the vial of "excision repair cross-complementing rodent repair deficiency, complementation group 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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