Mouse excision repair cross-complementing rodent repair deficiency, complementation group 2 ELISA Kit | ERCC2 elisa kit
Mouse TFIIH basal transcription factor complex helicase XPD subunit, ERCC2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ERCC2: ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. Might also have a role in aging process and could play a causative role in the generation of skin cancers. Belongs to the helicase family. RAD3/XPD subfamily. One of the six subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. The interaction with GTF2H2 results in the stimulation of the 5'-->3' helicase activity. Interacts with Epstein-Barr virus EBNA2.
Protein type: EC 3.6.4.12; Helicase
Cellular Component: cytoskeleton; holo TFIIH complex; cytoplasm; spindle; nucleus; cyclin-dependent protein kinase activating kinase holoenzyme complex
Molecular Function: protein C-terminus binding; DNA-dependent ATPase activity; hydrolase activity; metal ion binding; nucleotide binding; iron-sulfur cluster binding; ATP-dependent helicase activity; protein N-terminus binding; helicase activity; protein kinase activity; RNA polymerase subunit kinase activity; ATP-dependent DNA helicase activity; DNA binding; nucleic acid binding; 4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; ATP binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Biological Process: transcription from RNA polymerase II promoter; skin development; extracellular matrix organization and biogenesis; erythrocyte maturation; apoptosis; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; bone mineralization; embryonic cleavage; post-embryonic development; chromosome segregation; hair cycle process; UV protection; regulation of transcription, DNA-dependent; transcription-coupled nucleotide-excision repair; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; aging; response to UV; positive regulation of DNA binding; transcription, DNA-dependent; in utero embryonic development; multicellular organism growth; hair cell differentiation; nucleotide-excision repair, DNA incision; DNA repair; hair follicle maturation; DNA duplex unwinding; cell proliferation; myelin formation in the central nervous system; spinal cord development; nucleotide-excision repair; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; response to DNA damage stimulus
Research Articles on ERCC2
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Product Notes
The Mouse ERCC2 ercc2 (Catalog #AAA9327529) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327529 ELISA Kit recognizes Mouse ERCC2. It is sometimes possible for the material contained within the vial of "excision repair cross-complementing rodent repair deficiency, complementation group 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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