GTPase Era, mitochondrial (ERAL1) Recombinant Protein | ERAL1 recombinant protein

Recombinant Human GTPase Era, mitochondrial (ERAL1)

Cat. Num. AAA1159226

• Gene Names: ERAL1; ERA; CEGA; ERA-W; H-ERA; ERAL1A; ERAL1B; HERA-A; HERA-B; PRLTS6
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: GTPase Era; mitochondrial (ERAL1); Recombinant Human GTPase Era; ERAL1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 44-437, Full length protein
• Sequence: VSCVAGSAFSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHLPQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLMDIFLCDVDIRLSVKLLK
• Sequence Length: 394

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 966209847
• NCBI GeneID: 26284
• NCBI Accession #: NP_001304914.1
• NCBI GenBank Nucleotide #: NM_001317985.1
• UniProt Accession #: O75616; O75617; Q8WUY4; Q96LE2; Q96TC0; B3KN21; C9JEC6
• Molecular Weight: 30,040 Da
• NCBI Official Full Name: GTPase Era, mitochondrial isoform 2
• NCBI Official Synonym Full Names: Era like 12S mitochondrial rRNA chaperone 1
• NCBI Official Symbol: ERAL1
• NCBI Official Synonym Symbols: ERA; CEGA; ERA-W; H-ERA; ERAL1A; ERAL1B; HERA-A; HERA-B; PRLTS6
• NCBI Protein Information: GTPase Era, mitochondrial
• UniProt Protein Name: GTPase Era, mitochondrial
• UniProt Gene Name: ERAL1
• UniProt Synonym Gene Names: HERA; H-ERA; hERA; CEGA

NCBI Description

The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Description

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.