Butyrylcholinesterase Active Protein | BCHE active protein

Butyryl Cholinesterase

Cat. Num. AAA173029

• Gene Names: BCHE; E1; CHE1; CHE2
• Synonyms: Butyrylcholinesterase; Butyryl Cholinesterase; BCHE; BuChE; PCHE; pseudocholinesterase; plasma cholinesterase; Acylcholine acyl-hydrolase; Choline esterase; butyryl; Butyrylcholinesterase (BCHE); Horse Serum; BCHE active protein

• Host: Equine Serum
• Form/Format: Lyophilized powder
• Sequence Length: 602

• Appearance: White to pale grey-green powder
• Activity: 120 U/mg solid (Siemens Dimension® Clinical Chemistry System)
• Unit Definition: A change of 0.2 milliabsorbance units (mA) per minute corresponds to pseudocholinesterase activity of 1 U/mL at 37°C.
• Protein: 0.18 mg protein/mg solid (E^0.1%_280nm= 1.36)
• Specific Activity: 660 U/mg protein
• Reconstitution: Reconstitute at 5 mg/mL using 50 mM Tris-HCl pH 7.3 - 7.5.
• E.C. Number: 3.1.1.8
• Handling: Handle as a potentially hazardous substance.
• CAS Number: 9001-08-5
• Preparation and Storage: Store at -20°C. Protect from moisture. Ships on blue ice.

Product Categories/Family for BCHE active protein

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Butyrylcholinesterase (bche)

NCBI and Uniprot Product Information

• NCBI GI #: 17390312
• NCBI GeneID: 590
• NCBI Official Full Name: Butyrylcholinesterase
• NCBI Official Synonym Full Names: butyrylcholinesterase
• NCBI Official Symbol: BCHE
• NCBI Official Synonym Symbols: E1; CHE1; CHE2
• NCBI Protein Information: cholinesterase; cholinesterase 1; choline esterase II; pseudocholinesterase; butyrylcholine esterase; cholinesterase (serum) 2; acylcholine acylhydrolase
• UniProt Protein Name: Cholinesterase
• Protein Family: Cholinesterase
• UniProt Gene Name: BCHE
• UniProt Synonym Gene Names: CHE1
• UniProt Entry Name: CHLE_HUMAN

NCBI Description

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

Uniprot Description

BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.

Protein type: Secreted; Hydrolase; EC 3.1.1.8; Nuclear envelope; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: membrane; endoplasmic reticulum lumen; nuclear envelope lumen; extracellular region

Molecular Function: identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity

Biological Process: response to alkaloid; response to drug; negative regulation of cell proliferation; choline metabolic process; cocaine metabolic process; cellular protein metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission