Mouse Erythropoietin ELISA Kit | Epo elisa kit

Mouse Erythropoietin ELISA Kit

Cat. Num. AAA2880680

• Reactivity: Mouse
• Synonyms: Erythropoietin; Mouse Erythropoietin ELISA Kit; Epo; Epo elisa kit

• Reactivity: Mouse
• Sequence Length: 192

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/mL
• Sensitivity: 39.4 pg/mL
• Intra-Assay CV: <=5.4%
• Inter-Assay CV: <=7.6%
• Recovery: 94%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 21389309
• NCBI GeneID: 13856
• NCBI Accession #: NP_031968.1
• NCBI GenBank Nucleotide #: NM_007942.2
• UniProt Accession #: P07321
• Molecular Weight: 21,365 Da
• NCBI Official Full Name: erythropoietin isoform 1
• NCBI Official Synonym Full Names: erythropoietin
• NCBI Official Symbol: Epo
• NCBI Protein Information: erythropoietin
• UniProt Protein Name: Erythropoietin
• Protein Family: Erythropoietin
• UniProt Gene Name: Epo
• UniProt Entry Name: EPO_MOUSE

NCBI Description

This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Uniprot Description

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: cell surface; extracellular region; extracellular space

Molecular Function: erythropoietin receptor binding; hormone activity; protein kinase activator activity

Biological Process: angiogenesis; apoptosis; cardiac muscle morphogensis; embryo implantation; erythrocyte differentiation; erythrocyte maturation; heart morphogenesis; hemoglobin biosynthetic process; negative regulation of apoptosis; negative regulation of myeloid cell apoptosis; negative regulation of transcription from RNA polymerase II promoter; peptidyl-serine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of neuron differentiation; positive regulation of protein kinase activity; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of transcription from RNA polymerase II promoter; response to hypoxia; ventricular cardiac muscle morphogenesis