EPH Receptor B4 Recombinant Protein | EPHB4 recombinant protein
Recombinant Mouse EPH Receptor B4
EPHB4 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Introduction: Ephrin type-B receptor 4 isoform b (Ephb4) belongs to the Eph receptor tyrosine kinase family which functions in neuronal guidance and mediate venal/arterial separation. EPHB4-mediated forward signaling regulates cellular repulsion and segregation form EFNB2-expressing cells. Furthermore, Ephb4 has a role in postnatal blood vessel remodeling, morphogenesis and permeability and is therefore essential in the context of tumor angiogenesis.
NCBI and Uniprot Product Information
Uniprot Description
EphB4: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component: integral to plasma membrane
Molecular Function: ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: angiogenesis; cell adhesion; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; protein amino acid autophosphorylation; venous blood vessel morphogenesis
Research Articles on EPHB4
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Product Notes
The EPHB4 ephb4 (Catalog #AAA146922) is a Recombinant Protein produced from Sf9, Baculovirus cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: LEETLLNTKL ETADLKWVTY PQAEGQWEEL SGLDEEQHSV RTYEVCDMKR PGGQAHWLRT GWVPRRGAVH VYATIRFTMM ECLSLPRASR SCKETFTVFY YESEADTATA HTPAWMENPY IKVDTVAAEH LTRKRPGAEA TGKVNIKTLR LGPLSKAGFY LAFQDQGACM ALLSLHLFYK KCSWLITNLT YFPETVPREL VVPVAGSCVA NAVPTANPSP SLYCREDGQW AEQQVTGCSC APGYEAAESN KVCRACGQGT FKPQIGDESC LPCPANSHSN NIGSPVCLCR IGYYRARSDP RSSPCTTPPS APRSVVHHLN GSTLRLEWSA PLESGGREDL TYAVRCRECR PGGSCLPCGG DMTFDPGPRD LVEPWVAIRG LRPDVTYTFE VAALNGVSTL ATGPPPFEPV NVTTDREVPP AVSDIRVTRS SPSSLILSWA IPRAPSGAVL DYEVKYHEKG AEGPSSVRFL KTSENRAELR GLKRGASYLV QVRARSEAGY GPFGQEHHSQ TQLDESESWR EQLAVEH HHHHH. . It is sometimes possible for the material contained within the vial of "EPH Receptor B4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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