Ephrin type-A receptor 7 (Epha7) Recombinant Protein | Epha7 recombinant protein

Recombinant Rat Ephrin type-A receptor 7 (Epha7), partial

Cat. Num. AAA954315

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ephrin type-A receptor 7 (Epha7); Recombinant Rat Ephrin type-A receptor 7 (Epha7); partial; Epha7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 28-555
• Sequence: QAA KEVLLLDSKA QQTELEWISS PPSGWEEISG LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAVFPDTVT GSEFSSLVEV RGTCVSSAEE EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RRFYKSSSQD LQCSRCPTHS FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY YEKDQRERTY STLKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEASG KMFEATAVSS EQNPV
• Sequence Length: 528

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Epha7 recombinant protein

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

NCBI and Uniprot Product Information

• NCBI GI #: 19705437
• NCBI GeneID: 171287
• NCBI Accession #: NP_599158.1
• NCBI GenBank Nucleotide #: NM_134331.1
• UniProt Accession #: P54759
• Molecular Weight: 111,848 Da
• NCBI Official Full Name: ephrin type-A receptor 7
• NCBI Official Synonym Full Names: Eph receptor A7
• NCBI Official Symbol: Epha7
• NCBI Protein Information: ephrin type-A receptor 7
• UniProt Protein Name: Ephrin type-A receptor 7
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha7
• UniProt Synonym Gene Names: Ehk-3; Ehk3; EHK-3

NCBI Description

receptor for members of the ephrin-A subfamily of receptor tyrosine kinases; binds with ephrin-A1, -A2, -A3, -A4 and -A5, may mediate developmental effects in the nervous system [RGD, Feb 2006]

Uniprot Description

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.