Cholesterol Esterase Enzyme | CEL enzyme
Cholesterol Esterase (Carboxyl Ester Lipase, CEL, Lysophosphatidylcholine, Bile salt-stimulated lipase, BAL, BSDL, BSSL, Bucelipase, CEase, CELL,, lysoPC, PTL, Pancreatic triglyceride lipase, FAP, FAPP, LIPA, MODY8, Pancreatic lysophospholipase, Sterol es
For hydrolysis: 6.6-7.0 (17).
Histidine: (H435)
Aspartate: (D320)
NCBI and Uniprot Product Information
Hexamer: 400kD (8)
NCBI Description
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
Catalytic activity: Triacylglycerol + H2O = diacylglycerol + a carboxylate. Ref.9A steryl ester + H2O = a sterol + a fatty acid. Ref.9
Enzyme regulation: Activated by bile salts containing a 7-hydroxyl group.
Subunit structure: Interacts with CLC. Ref.13
Subcellular location: Secreted.
Tissue specificity: Mammary gland and pancreas. Expressed by eosinophils. Ref.13
Involvement in disease: Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8) [MIM:609812]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.Note: The disease is caused by mutations affecting the gene represented in this entry. The disease can be caused by frameshift deletions in the variable number of tandem repeats (VNTR)-containing exon 11 of the CEL gene (Ref.15). Ref.15
Sequence similarities: Belongs to the type-B carboxylesterase/lipase family.
Biophysicochemical propertiesKinetic parameters:KM=24 µM for lipoyl-4-aminobenzoate Ref.9KM=15 µM for triacetinVmax=45.5 pmol/min/mg enzyme toward lipoyl-4-aminobenzoateVmax=323 pmol/min/mg enzyme toward triacetin
Sequence caution: The sequence AAA51973.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA52014.1 differs from that shown. Reason: Erroneous initiation. The sequence AAC26514.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA38325.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI13412.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW88033.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on CEL
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Product Notes
The CEL cel (Catalog #AAA653957) is an Enzyme and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cholesterol Esterase, Enzyme" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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