ADGRE2 recombinant protein

Recombinant Human ADGRE2 protein

Cat. Num. AAA1561455

• Gene Names: EMR2; CD312
• Purity: >90% as determined by SDS-PAGE
• Synonyms: ADGRE2; Recombinant Human ADGRE2 protein; Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD312; ADGRE2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human ADGRE2 (Asn347-Ser509) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for ADGRE2 recombinant protein

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.

Product Categories/Family for ADGRE2 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 23397681
• NCBI GeneID: 30817
• NCBI Accession #: NP_038475.2
• NCBI GenBank Nucleotide #: NM_013447.3
• UniProt Accession #: Q9UHX3; Q8NG96; Q9Y4B1; E9PBR1; E9PEL6; E9PFQ5; E9PG91
• Molecular Weight: 90,472 Da
• NCBI Official Full Name: EGF-like module-containing mucin-like hormone receptor-like 2 isoform a
• NCBI Official Synonym Full Names: egf-like module containing, mucin-like, hormone receptor-like 2
• NCBI Official Symbol: EMR2
• NCBI Official Synonym Symbols: CD312
• NCBI Protein Information: EGF-like module-containing mucin-like hormone receptor-like 2
• UniProt Protein Name: EGF-like module-containing mucin-like hormone receptor-like 2
• UniProt Gene Name: EMR2
• UniProt Entry Name: EMR2_HUMAN

NCBI Description

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Description

EMR2: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell migration; cell adhesion; inflammatory response