Typical Testing Data/Standard Curve (for reference only)
BMP-2 elisa kit
BMP-2 ELISA Kit
Gene Names
BMP2; BDA2; BMP2A
Synonyms
BMP-2; BMP-2 ELISA Kit; Bone morphogenetic protein 2; BMP-2 elisa kit
Specificity
The specificity is defined as the probability of the assay of scoring negative in the absence of the specific analyte. It is 95 %.
Sequence Length
396
Samples
Human Serum Or Plasma
Preparation and Storage
2 - 8 degree C
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for BMP-2 elisa kit
Intended Uses: The BioSource Ascaris lumbricoides IgG-ELISA is intended for the determination of IgG class antibodies against Ascaris lumbricoides in human serum or plasma (citrate). For research use only.
Principle of the Assay: The immunoenzymatic determination of IgG-class antibodies against Ascaris lumbricoides is based on the ELISA (Enzyme-linked Immunosorbent Assay) technique. Microtiter strip wells are precoated with Ascaris lumbricoides antigens to bind corresponding antibodies of the unknown. After washing the wells to remove all unbound unknown material horseradish peroxidase (HRP) labelled Protein A conjugate is added. This conjugate binds to antigen-antibody complexes. The immune complex formed by the bound conjugate is visualized by adding Tetramethylbenzidine (TMB) substrate which gives a blue reaction product. The intensity of this product is proportional to the amount of Ascaris-specific IgG antibodies in the specimen. Acidic solution is added to stop the reaction. This produces a yellow endpoint colour. Absorbance at 450 nm is read using an ELISA microwell plate reader!!Background/Introduction: Ascaridae are big nematodes. The male individuals are up to 25 cm, the female ones are up to 40 cm long. Ascaris lumbricoides is among the Ascaridae the species with the highest importance for human medicine, because it is the only one with humans as main host. The sexually mature roundworm lives in the small intestine. The females produce up to 200 000 eggs daily, which attain to the environment by faeces. Infectious larvae develop inside the eggs and after oral ingestion they hatch in the upper part of the small intestine. They penetrate the wall of the intestine and get into the venous blood with which they get into liver and lung, where they leave the vessels and skin in the aveoles. The larvae migrate into the trachea and through the pharynx after swallowing back to the small intestine where the maturation to the adult worm takes place. Ca. 10-12 weeks after infestation the roundworms will be excreted with faeces. The adult worm lives for around 18 months. Ascaris lumbricoides is one of the most abundant exciter of infectious diseases worldwide. Main endemic areas are Eastern Asia, Africa and Middle and South America. Children are more often affected than adults. The infestation leads to Ascariasis mostly with latent progression. The migrating larvae can lead to inflammatory, eosinophile infiltration of the lung and cause cough, dyspnoea and light fever. Conglomerates of the worms can cause intestinal blockage. If the worms migrate into gall, pancreas or stomach the corresponding clinical symptoms result.
Principle of the Assay: The immunoenzymatic determination of IgG-class antibodies against Ascaris lumbricoides is based on the ELISA (Enzyme-linked Immunosorbent Assay) technique. Microtiter strip wells are precoated with Ascaris lumbricoides antigens to bind corresponding antibodies of the unknown. After washing the wells to remove all unbound unknown material horseradish peroxidase (HRP) labelled Protein A conjugate is added. This conjugate binds to antigen-antibody complexes. The immune complex formed by the bound conjugate is visualized by adding Tetramethylbenzidine (TMB) substrate which gives a blue reaction product. The intensity of this product is proportional to the amount of Ascaris-specific IgG antibodies in the specimen. Acidic solution is added to stop the reaction. This produces a yellow endpoint colour. Absorbance at 450 nm is read using an ELISA microwell plate reader!!Background/Introduction: Ascaridae are big nematodes. The male individuals are up to 25 cm, the female ones are up to 40 cm long. Ascaris lumbricoides is among the Ascaridae the species with the highest importance for human medicine, because it is the only one with humans as main host. The sexually mature roundworm lives in the small intestine. The females produce up to 200 000 eggs daily, which attain to the environment by faeces. Infectious larvae develop inside the eggs and after oral ingestion they hatch in the upper part of the small intestine. They penetrate the wall of the intestine and get into the venous blood with which they get into liver and lung, where they leave the vessels and skin in the aveoles. The larvae migrate into the trachea and through the pharynx after swallowing back to the small intestine where the maturation to the adult worm takes place. Ca. 10-12 weeks after infestation the roundworms will be excreted with faeces. The adult worm lives for around 18 months. Ascaris lumbricoides is one of the most abundant exciter of infectious diseases worldwide. Main endemic areas are Eastern Asia, Africa and Middle and South America. Children are more often affected than adults. The infestation leads to Ascariasis mostly with latent progression. The migrating larvae can lead to inflammatory, eosinophile infiltration of the lung and cause cough, dyspnoea and light fever. Conglomerates of the worms can cause intestinal blockage. If the worms migrate into gall, pancreas or stomach the corresponding clinical symptoms result.
Product Categories/Family for BMP-2 elisa kit
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
44,702 Da
NCBI Official Full Name
bone morphogenetic protein 2
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
BMP2
NCBI Official Synonym Symbols
BDA2; BMP2A
NCBI Protein Information
bone morphogenetic protein 2
UniProt Protein Name
Bone morphogenetic protein 2
Protein Family
UniProt Gene Name
BMP2
UniProt Synonym Gene Names
BMP2A; BMP-2; BMP-2A
UniProt Entry Name
BMP2_HUMAN
NCBI Description
This gene encodes a member of the transforming growth factor-beta (TGFB) superfamily. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which induces bone and cartilage formation. [provided by RefSeq, Nov 2015]
Uniprot Description
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Research Articles on BMP-2
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Product Notes
The BMP-2 bmp2 (Catalog #AAA495317) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BMP-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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