Human eukaryotic translation initiation factor 2 alpha kinase 4 ELISA Kit | EIF2AK4 elisa kit
Human Eukaryotic translation initiation factor 2-alpha kinase 4, EIF2AK4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Uniprot Description
GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
Protein type: Protein kinase, Other; Translation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; PEK family; GCN2 subfamily
Chromosomal Location of Human Ortholog: 15q15.1
Molecular Function: protein serine/threonine kinase activity; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity
Biological Process: unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation
Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive
Research Articles on EIF2AK4
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Product Notes
The Human EIF2AK4 eif2ak4 (Catalog #AAA9324956) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324956 ELISA Kit recognizes Human EIF2AK4. It is sometimes possible for the material contained within the vial of "eukaryotic translation initiation factor 2 alpha kinase 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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