Rat eukaryotic translation initiation factor 2-alpha kinase 3 ELISA Kit | EIF2AK3 elisa kit
Rat Eukaryotic translation initiation factor 2-alpha kinase 3, EIF2AK3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
kinase that phosphorylates eukaryotic initiation factor 2alpha; has an important role in translational control [RGD, Feb 2006]
Uniprot Description
PERK: a transmembrane protein kinase of the PEK family resident in the endoplasmic reticulum (ER) membrane and is linked to insulin processing. Couples ER stress to translation inhibition. Stress induces autophosphorylation of its kinase domain and increases its activity. Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. A critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin d1. Forms dimers with BiP in resting cells. Oligomerizes in ER-stressed cells. LOF mutations cause Wolcott-Rallison syndrome (WRS), characterized by insulin-dependent diabetes in early infancy and, later, multiple system abnormalities. Neuronal death in Alzheimer?s and Parkinson?s diseases is thought to be due to ER stress and has been weakly linked to PEK.
Protein type: Protein kinase, Other; Kinase, protein; Translation; EC 2.7.11.1; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Other group; PEK family; PEK subfamily
Cellular Component: endoplasmic reticulum membrane; membrane; cell; endoplasmic reticulum; cytoplasm; integral to membrane; intracellular
Molecular Function: protein serine/threonine kinase activity; identical protein binding; enzyme binding; protein phosphatase binding; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein kinase activity
Biological Process: lactation; fat cell differentiation; translation; positive regulation of protein binding; protein amino acid autophosphorylation; protein amino acid phosphorylation; bone mineralization; positive regulation of transcription from RNA polymerase I promoter; cellular response to glucose starvation; negative regulation of translation in response to stress; regulation of fatty acid metabolic process; pancreas development; angiogenesis; skeletal development; ER overload response; protein homooligomerization; caspase activation; endoplasmic reticulum organization and biogenesis; ossification; negative regulation of myelination; positive regulation of signal transduction; unfolded protein response; calcium-mediated signaling; chondrocyte development; SREBP-mediated signaling pathway; endocrine pancreas development; insulin-like growth factor receptor signaling pathway; negative regulation of translation; negative regulation of translation initiation in response to stress; negative regulation of apoptosis
Research Articles on EIF2AK3
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Product Notes
The Rat EIF2AK3 eif2ak3 (Catalog #AAA9329526) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329526 ELISA Kit recognizes Rat EIF2AK3. It is sometimes possible for the material contained within the vial of "eukaryotic translation initiation factor 2-alpha kinase 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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