NCBI and Uniprot Product Information
NCBI Description
catalyzes the translocation of peptidyl-tRNA from the ribosomal A site to the P site in translational elongation [RGD, Feb 2006]
Uniprot Description
EEF2: a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation.
Protein type: Translation elongation; Translation
Cellular Component: cytoplasm; cytosol; lipid raft; membrane; nucleus; plasma membrane; polysomal ribosome; polysome; ribonucleoprotein complex
Molecular Function: 5S rRNA binding; actin filament binding; GTP binding; GTPase activity; p53 binding; protein kinase binding; ribosome binding; RNA binding; translation elongation factor activity
Biological Process: aging; glial cell proliferation; hemopoietic progenitor cell differentiation; positive regulation of translation; response to estradiol stimulus; response to ethanol; response to fluoxetine; response to folic acid; response to hydrogen peroxide; skeletal muscle contraction; translational elongation
Research Articles on Eef2
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Product Notes
The Rat Eef2 eef2 (Catalog #AAA289566) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA289566 ELISA Kit recognizes Rat Eef2. It is sometimes possible for the material contained within the vial of "Elongation factor 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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