ESX-1 secretion system protein EccCa1 (eccCa1) Recombinant Protein | eccCa1 recombinant protein
Recombinant ESX-1 secretion system protein EccCa1 (eccCa1)
NCBI and Uniprot Product Information
Uniprot Description
Function: Part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis. Ref.3 Ref.4
Subunit structure: Part of the ESX-1 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. Interacts with EccCb1. Ref.3
Subcellular location: Cell membrane; Multi-pass membrane protein
Potential.
Disruption phenotype: Disruption abolishes EsxA and EsxB secretion, which results in a lack of antigen specific immunogenicity and leads to attenuated virulence. Does not affect their expression. Ref.3 Ref.4
Miscellaneous: In ESX-1 cluster, the FtsK/SpoIIIE-like protein is split in two genes.
Sequence similarities: Contains 1 FtsK domain.
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Product Notes
The ESX-1 secretion system protein EccCa1 (eccCa1) eccca1 (Catalog #AAA1176763) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-747. The amino acid sequence is listed below: MTTKKFTPTI TRGPRLTPGE ISLTPPDDLG IDIPPSGVQK ILPYVMGGAM LGMIAIMVAG GTRQLSPYML MMPLMMIVMM VGGLAGSTGG GGKKVPEINA DRKEYLRYLA GLRTRVTSSA TSQVAFFSYH APHPEDLLSI VGTQRQWSRP ANADFYAATR IGIGDQPAVD RLLKPAVGGE LAAASAAPQP FLEPVSHMWV VKFLRTHGLI HDCPKLLQLR TFPTIAIGGD LAGAAGLMTA MICHLAVFHP PDLLQIRVLT EEPDDPDWSW LKWLPHVQHQ TETDAAGSTR LIFTRQEGLS DLAARGPHAP DSLPGGPYVV VVDLTGGKAG FPPDGRAGVT VITLGNHRGS AYRIRVHEDG TADDRLPNQS FRQVTSVTDR MSPQQASRIA RKLAGWSITG TILDKTSRVQ KKVATDWHQL VGAQSVEEIT PSRWRMYTDT DRDRLKIPFG HELKTGNVMY LDIKEGAEFG AGPHGMLIGT TGSGKSEFLR TLILSLVAMT HPDQVNLLLT DFKGGSTFLG MEKLPHTAAV VTNMAEEAEL VSRMGEVLTG ELDRRQSILR QAGMKVGAAG ALSGVAEYEK YRERGADLPP LPTLFVVVDE FAELLQSHPD FIGLFDRICR VGRSLRVHLL LATQSLQTGG VRIDKLEPNL TYRIALRTTS SHESKAVIGT PEAQYITNKE SGVGFLRVGM EDPVKFSTFY ISGPYMPPAA GVETNGEAGG PGQQTTRQAA RIHRFTAAPV LEEAPTP. It is sometimes possible for the material contained within the vial of "ESX-1 secretion system protein EccCa1 (eccCa1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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