Relaxin-3 Active Protein | RLN3 active protein

Recombinant Human Relaxin-3

Cat. Num. AAA140915

• Gene Names: RLN3; H3; RXN3; ZINS4; insl7
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Relaxin-3; Recombinant Human Relaxin-3; RLN3 Human; Relaxin-3 Human Recombinant; Relaxin 3; Prorelaxin H3; RXN3; Insulin-Like Peptide INSL7; Insulin-Like Peptide 7; Insl7; ZINS4; H3; Relaxin 3 (H3); Insulin-Like 7; RLN3; RLN3 active protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution in Acetonitrile and TFA.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: A chain: DVLAGLSSSC CKWGCSKSEI SSLCB chain: RAAPYGVRLCG REFIRAVIFT CGGSRW
• Sequence Length: 109

• Biological Activity: The ED50, as measured by cAMP accumulation in human THP-1 cells, is less than 17.5ng/ml.
• Solubility: It is recommended to reconstitute the lyophilized RLN3 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized RLN3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Relaxin-3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for RLN3 active protein

Introduction: Relaxin-3 (RLN3) belongs to the relaxin family. Relaxins being endocrine and autocrine/paracrine hormones are members of the insulin gene superfamily. Relaxin, which is produced by the ovary, targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. Unlike human Relaxins 1 and 2, Relaxin 3 does not seem to have a role in reproduction; however it is involved in stress response in the brain stem. RLN3 is the only known ligand for the G-protein-coupled receptor GPCR135, titled RXFP3. In addition, RLN3 binds the LGR7 (RXFP1) receptor, however with lower affinity than Relaxin-2. Even though binding of RLN3 to LGR7 increases intracellular cAMP, binding to GPCR135 suppresses cAMP accumulation, indicating coupling to Gi, Go, or Gz by this receptor.

Description: Relaxin-3 Human Recombinant produced in E Coli is a disulfide-linked heterodimeric, non-glycosylated, polypeptide chain containing 24 amino acids for A chain and 27 amino acids for B chain and having a molecular mass of 2.5kDa for A chain and 3kDa for B chain.The Relaxin-3 is purified by proprietary chromatographic techniques.

Product Categories/Family for RLN3 active protein

Recombinant & Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 909618058
• NCBI GeneID: 117579
• NCBI Accession #: NP_001298126.1
• NCBI GenBank Nucleotide #: NM_001311197.1
• UniProt Accession #: Q8WXF3; Q6UXW5
• Molecular Weight: 15,451 Da
• NCBI Official Full Name: relaxin-3
• NCBI Official Synonym Full Names: relaxin 3
• NCBI Official Symbol: RLN3
• NCBI Official Synonym Symbols: H3; RXN3; ZINS4; insl7
• NCBI Protein Information: relaxin-3
• UniProt Protein Name: Relaxin-3
• Protein Family: Relaxin
• UniProt Gene Name: RLN3
• UniProt Synonym Gene Names: INSL7; RXN3; ZINS4; Insulin-like peptide 7
• UniProt Entry Name: REL3_HUMAN

Uniprot Description

RLN3: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular region

Molecular Function: G-protein-coupled receptor binding; hormone activity; protein binding