G-CSF active protein

Rat G-CSF

Cat. Num. AAA691792

• Gene Names: Csf3; Gcsf
• Reactivity: Rat
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Synonyms: G-CSF; Rat G-CSF; Granulocyte Colony-Stimulating Factor; CSF-3; MGI-1G; GM-CSFbeta; pluripoietin; G-CSF active protein

• Host: E Coli
• Reactivity: Rat
• Purity/Purification: > 98% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: MKKIPLLTVS SLPPSLPLPR SFLLKSLEQV RKIQARNTEL LEQLCA TYKL CHPEELVLFG HSLGIPKASL SSCSSQALQQ TKCLSQLHSG L FLYQGLLQA LAGISSELAP TLDMLHLDVD NFATTIWQQM ESLGVAP TVQ PTQSTMPIFT SAFQRRAGGV LVTSYLQSFL ETAHHALHHL PR PAQKHFPE SLFISI
• Sequence Length: 214

• Biological Activity: Determined by its ability to stimulate the proliferation of mouse NFS-60 cells. The expected ED50 is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107 units/mg.

Related Product Information for G-CSF active protein

G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Recombinant rat G-CSF is a 21.6 kDa protein consisting of 196 amino acid residues.

Product Categories/Family for G-CSF active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 8393200
• NCBI GeneID: 25610
• NCBI Accession #: NP_058800.1
• NCBI GenBank Nucleotide #: NM_017104.1
• UniProt Accession #: P97712
• Molecular Weight: 23,660 Da
• NCBI Official Full Name: granulocyte colony-stimulating factor
• NCBI Official Synonym Full Names: colony stimulating factor 3 (granulocyte)
• NCBI Official Symbol: Csf3
• NCBI Official Synonym Symbols: Gcsf
• NCBI Protein Information: granulocyte colony-stimulating factor
• UniProt Protein Name: Granulocyte colony stimulating factor
• UniProt Gene Name: Csf3
• UniProt Entry Name: P97712_RAT

NCBI Description

putative hematopoetic growth factor for neutrophils; used as a treatment for cyclic hematopoesis in humans and dogs [RGD, Feb 2006]

Uniprot Description

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell cycle regulation

Cellular Component: extracellular space

Molecular Function: enzyme binding; growth factor activity; cytokine activity

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; positive regulation of actin filament polymerization; positive regulation of protein binding; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation