Peptidylprolyl Isomerase D Active Protein | mPPID active protein

Recombinant Mouse Peptidylprolyl Isomerase D

Cat. Num. AAA141244

• Gene Names: Ppid; Ppidl; CYP-40; 4930564J03Rik
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Peptidylprolyl Isomerase D; Recombinant Mouse Peptidylprolyl Isomerase D; Peptidylprolyl Isomerase D Mouse Recombinant; Peptidyl-prolyl cis-trans isomerase D; PPIase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; CYP40; CYPD; PPID; PPID Mouse; mPPID active protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: Sterile filtered colorless solution.; Protein solution (1mg/ml) containing 20mM Tris-Hcl buffer (pH8.0), 10% glycerol and 1mM DTT.
• Sequence Length: 370

• Biological Activity: Specific activity is > 700nmol/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-PNA per minute at 37 degree C in Tris-HCl pH 8.0 using chymotrypsin.
• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Please prevent freeze-thaw cycles.

Related Product Information for mPPID active protein

Description: PPID Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 395 amino acids (1-370a.a.) and having a molecular mass of 43.4kDa. PPID is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introductions: Cyclophilin-D is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and speeds up the protein folding. Cyclophilin-D possess PPIase activity and binds to the immunosuppressant cyclosporin-A. Cyclophilin-D is very well known that its overexpression suppresses the apoptosis in cancer cell. Cyclophilin-D suppresses apoptotic cell death by the use of mitochondrial hexokinase-2 dependent mechanism in cancer cells.

Product Categories/Family for mPPID active protein

Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 23396571
• NCBI GeneID: 67738
• UniProt Accession #: Q9CR16; Q543G1
• Molecular Weight: 40,743 Da
• NCBI Official Full Name: Peptidyl-prolyl cis-trans isomerase D
• NCBI Official Synonym Full Names: peptidylprolyl isomerase D (cyclophilin D)
• NCBI Official Symbol: Ppid
• NCBI Official Synonym Symbols: Ppidl; CYP-40; 4930564J03Rik
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase D
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase D
• Protein Family: Peptidylprolyl isomerase domain and WD repeat-containing protein
• UniProt Gene Name: Ppid
• UniProt Synonym Gene Names: PPIase DBy similarityManual assertion inferred from sequence similarity toiUniProtKB:Q08752Â (PPID_HUMAN); CYP-40By similarityManual assertion inferred from sequence similarity toiUniProtKB:Q08752Â (PPID_HUMAN)

Uniprot Description

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis.