TRAIL active protein
Mouse TRAIL
Gene Names
Tnfsf10; TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik
Reactivity
Mouse
Purity
> 95% by SDS-PAGE
Synonyms
TRAIL; Mouse TRAIL; Recombinant Murine TRAIL; TRAIL active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Lyophilized
Sequence
MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRK GHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS K DKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQ GGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN
Sequence Length
291
Endotoxin Level
< 0.1 ng per ug of TRAIL
Biological Activity
Assay#1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml. Assay#2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40.0-60.0 ng/ml.
Related Product Information for TRAIL active protein
TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell's apoptotic machinery. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.
Product Categories/Family for TRAIL active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
20.0 kDa
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 10
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 10
NCBI Official Symbol
Tnfsf10
NCBI Official Synonym Symbols
TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik
NCBI Protein Information
tumor necrosis factor ligand superfamily member 10; TRAIL/APO2L; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 10
UniProt Gene Name
Tnfsf10
UniProt Synonym Gene Names
Trail; Protein TRAIL
UniProt Entry Name
TNF10_MOUSE
Uniprot Description
Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subunit structure: Homotrimer
By similarity.
Subcellular location: Membrane; Single-pass type II membrane protein
Potential.
Tissue specificity: Widespread.
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on TRAIL
Similar Products
Product Notes
The TRAIL tnfsf10 (Catalog #AAA691694) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse TRAIL reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRK GHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS K DKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQ GGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN. It is sometimes possible for the material contained within the vial of "TRAIL, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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