MIP-1 beta active protein
Mouse MIP-1 beta
Gene Names
Ccl4; Act-2; Mip1b; Scya4; MIP-1B; AT744.1
Reactivity
Mouse
Purity
> 95% by SDS-PAGE
Synonyms
MIP-1 beta; Mouse MIP-1 beta; Recombinant Murine MIP-1 beta; MIP-1 beta active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Lyophilized
Sequence
APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKR GRQI CANPSEPWVT EYMSDLELN
Sequence Length
92
Endotoxin Level
< 0.1 ng per ug of MIP-1 beta
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 20.0-100.0 ng/ml.
Related Product Information for MIP-1 beta active protein
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1alpha and MIP-1beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Categories/Family for MIP-1 beta active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
7.8 kDa
NCBI Official Full Name
C-C motif chemokine 4
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 4
NCBI Official Symbol
Ccl4
NCBI Official Synonym Symbols
Act-2; Mip1b; Scya4; MIP-1B; AT744.1
NCBI Protein Information
C-C motif chemokine 4; ACT2; SIS-gamma; MIP-1 beta; MIP-1-beta; immune activation protein 2; small inducible cytokine A4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta
UniProt Protein Name
C-C motif chemokine 4
UniProt Gene Name
Ccl4
UniProt Synonym Gene Names
Mip1b; Scya4; ACT-2; ACT2; MIP-1-beta
UniProt Entry Name
CCL4_MOUSE
Uniprot Description
Function: Monokine with inflammatory and chemokinetic properties.
Subunit structure: Homodimer
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Research Articles on MIP-1 beta
Similar Products
Product Notes
The MIP-1 beta ccl4 (Catalog #AAA691963) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse MIP-1 beta reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKR GRQI CANPSEPWVT EYMSDLELN. It is sometimes possible for the material contained within the vial of "MIP-1 beta, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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