KC (CXCL1) active protein
Mouse KC (CXCL1)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
Uniprot Description
Function: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation
By similarity. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity. Ref.5
Subcellular location: Secreted.
Induction: By platelet-derived growth factor. In lung, by lipopolysaccharide or inflammation
By similarity.
Post-translational modification: The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Research Articles on KC (CXCL1)
Similar Products
Product Notes
The KC (CXCL1) cxcl1 (Catalog #AAA691637) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse KC (CXCL1) reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKN GREA CLDPEAPLVQ KIVQKMLKGV PK. It is sometimes possible for the material contained within the vial of "KC (CXCL1), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
