IFN-lambda2 active protein
Mouse IFN-lambda2
Gene Names
Ifnl2; Il28a; IL-28A; EG330496
Reactivity
Mouse
Purity
> 95% by SDS-PAGE and HPLC
Synonyms
IFN-lambda2; Mouse IFN-lambda2; Recombinant Murine IFN lambda-2; IFN-lambda2 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 95% by SDS-PAGE and HPLC
Form/Format
Lyophilized
Sequence
MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKA kDaI EKRLL EKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHR LQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV
Sequence Length
193
Endotoxin Level
< 0.1 ng per ug of IFN lambda-2
Biological Activity
Determined by its ability to activate STAT following receptor-ligand interaction.
Related Product Information for IFN-lambda2 active protein
Human/mouse IFN-lambda 2 or IL-28A, IL-28B (or IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.
Product Categories/Family for IFN-lambda2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19.8 kDa
NCBI Official Full Name
interferon lambda-2
NCBI Official Synonym Full Names
interferon lambda 2
NCBI Official Symbol
Ifnl2
NCBI Official Synonym Symbols
Il28a; IL-28A; EG330496
NCBI Protein Information
interferon lambda-2; IFN-lambda2; IFN-lambda-2; interleukin 28A; interleukin-28A; interferon-lambda2
UniProt Protein Name
Interferon lambda-2
UniProt Gene Name
Ifnl2
UniProt Synonym Gene Names
Il28a; IFN-lambda-2; IL-28A
UniProt Entry Name
IFNL2_MOUSE
Uniprot Description
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Ref.1 Ref.3 Ref.4 Ref.5
Subcellular location: Secreted
By similarity UniProtKB Q8IZJ0.
Sequence similarities: Belongs to the lambda interferon family.
Similar Products
Product Notes
The IFN-lambda2 ifnl2 (Catalog #AAA691977) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse IFN-lambda2 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKA kDaI EKRLL EKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHR LQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV. It is sometimes possible for the material contained within the vial of "IFN-lambda2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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