Neurotrophin-3 Active Protein | mNT 3 active protein

Recombinant Mouse Neurotrophin-3

Cat. Num. AAA143501

• Gene Names: Ntf3; Nt3; Ntf-3; AI316846; AI835689
• Purity: Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Synonyms: Neurotrophin-3; Recombinant Mouse Neurotrophin-3; NT 3 Mouse; Neurotrophin-3 Mouse Recombinant; Neurotrophic factor; Nerve growth factor-2; NGF-2; HDNF; NT-3; Ntf3; Ntf-3; AI316846; AI835689; Nt3; mNT 3 active protein

• Host: E Coli
• Purity/Purification: Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Form/Format: Lyophilized from 0.02% TFA.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: YAEHKSHRGE YSVCDSESLW VTDKSSAIDI RGHQVTVLGE IKTGNSPVKQ YFYETRCKEA RPVKNGCRGI DDKHWNSQCK TSQTYVRALT SENNKLVGWR WIRIDTSCVC ALSRKIGRT
• Sequence Length: 271

• Solubility: It is recommended to reconstitute the lyophilized Neurotrophin-3 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The activity, as determined by the dose-dependent proliferation of BaF3 cells transfected with the TrkB receptor, is typically in the range of 1-10 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg.
• Preparation and Storage: Lyophilized NGF2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution NGF-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for mNT 3 active protein

Introduction: NT3 a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

Product Categories/Family for mNT 3 active protein

Cytokines and Growth Factors; Neurotrophins

NCBI and Uniprot Product Information

• NCBI GI #: 255708383
• NCBI GeneID: 18205
• NCBI Accession #: NP_001157506.1
• NCBI GenBank Nucleotide #: NM_001164034.1
• UniProt Accession #: P20181
• Molecular Weight: 29,588 Da
• NCBI Official Full Name: neurotrophin-3 isoform a
• NCBI Official Synonym Full Names: neurotrophin 3
• NCBI Official Symbol: Ntf3
• NCBI Official Synonym Symbols: Nt3; Ntf-3; AI316846; AI835689
• NCBI Protein Information: neurotrophin-3; HDNF; NGF-2; nerve growth factor 2; neurotrophic factor
• UniProt Protein Name: Neurotrophin-3
• Protein Family: Neurotrophin
• UniProt Gene Name: Ntf3
• UniProt Synonym Gene Names: Ntf-3; NT-3; NGF-2
• UniProt Entry Name: NTF3_MOUSE

Uniprot Description

NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: neurotrophin p75 receptor binding; neurotrophin receptor binding; protein binding; growth factor activity; nerve growth factor binding; chemoattractant activity; receptor binding

Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; regulation of neuron differentiation; activation of MAPK activity; positive regulation of receptor internalization; positive regulation of glial cell differentiation; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; positive regulation of cell proliferation; regulation of neuron apoptosis; negative regulation of neuron apoptosis; regulation of synaptic transmission; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; generation of neurons; neuron development; neuromuscular synaptic transmission; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; nerve development; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration