Interleukin-1 alpha Active Protein | mIL 1 alpha active protein

Recombinant Mouse Interleukin-1 alpha

Cat. Num. AAA143183

• Gene Names: Il1a; Il-1a
• Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Synonyms: Interleukin-1 alpha; Recombinant Mouse Interleukin-1 alpha; IL 1 alpha Mouse; Interleukin-1 alpha Mouse Recombinant; Hematopoietin-1; Lymphocyte-activating factor (LAF); Endogenous Pyrogen (EP); Leukocyte Endogenous Mediator (LEM); Mononuclear Cell Factor (MCF); IL-1 alpha; IL1; IL-1A; IL1F1; mIL 1 alpha active protein

• Host: E Coli
• Purity/Purification: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Form/Format: The protein was lyophilized from a concentrated (1mg/ml) sterile solution containing 1X PBS, pH=7.4.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS
• Sequence Length: 270

• Solubility: It is recommended to reconstitute the lyophilized Interleukin 1a in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The ED50 as determined by the dose-dependant stimulation of murine D10S cells is < 0.01 ng/ml, corresponding to a Specific Activity of 100,000,000IU/mg.
• Preparation and Storage: Lyophilized Interleukin-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL1A should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for mIL 1 alpha active protein

Description: Interleukin-1A Mouse Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 156 amino acids and having a molecular mass of 18 kDa. The IL-1A is purified by proprietary chromatographic techniques.

Introduction: Interleukin-1 alpha is a proinflammatory cytokine produced by a wide variety of cell types, including macrophages, osteoblasts, monocytes and hepatocytes. Circulating levels of are normally low and only rise after stimulation by agents such as those produced byinflammation, infection or microbial endotoxins. IL-1 alpha possesses a wide variety of biological activities and exerts its effects by binding to specific cell surface receptors.

Product Categories/Family for mIL 1 alpha active protein

Cytokines and Growth Factors; Cytokines; Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 47059075
• NCBI GeneID: 16175
• NCBI Accession #: NP_034684.2
• NCBI GenBank Nucleotide #: NM_010554.4
• UniProt Accession #: P01582
• Molecular Weight: 31,023 Da
• NCBI Official Full Name: interleukin-1 alpha
• NCBI Official Synonym Full Names: interleukin 1 alpha
• NCBI Official Symbol: Il1a
• NCBI Official Synonym Symbols: Il-1a
• NCBI Protein Information: interleukin-1 alpha; IL-1 alpha
• UniProt Protein Name: Interleukin-1 alpha
• Protein Family: Interleukin
• UniProt Gene Name: Il1a
• UniProt Synonym Gene Names: IL-1 alpha
• UniProt Entry Name: IL1A_MOUSE

Uniprot Description

IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family.

Protein type: Motility/polarity/chemotaxis; Cytokine

Cellular Component: extracellular space; cell surface; extracellular region; plasma membrane; cytosol

Molecular Function: interleukin-1 receptor binding; copper ion binding; cytokine activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of interleukin-6 production; positive regulation of JNK cascade; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; connective tissue replacement during inflammatory response; positive regulation of angiogenesis; response to copper ion; positive regulation of cell division; keratinization; positive regulation of prostaglandin secretion; positive regulation of transcription from RNA polymerase II promoter; immune response; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion