CTACK active protein

Human CTACK (CCL27)

Cat. Num. AAA695756

• Gene Names: CCL27; ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27
• Reactivity: Species Reactivity: Human; Cross Reactivity: Mouse
• Purity: Above 98% as determined by SDS-PAGE Analysis.
• Synonyms: CTACK; Human CTACK (CCL27); Recombinant Human CTACK (CCL27); CTACK active protein

• Host: E Coli
• Reactivity: Species Reactivity: Human; Cross Reactivity: Mouse
• Purity/Purification: Above 98% as determined by SDS-PAGE Analysis.
• Sequence: FLLPPSTAC CTQLYRKPL SDKLLRKVI QVELQEADG DCHLQAFVL HLAQRSICI HPQNPSLSQ WFEHQERKL HGTLPKLNF GMLRKMG

• Biological Activity: Determined by its ability to chemoattract CXCR3 transfected cells using a concentration of 10.0-100.0 ng/ml.
• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for CTACK active protein

CTACK is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant human CTACK is a 10.2 kDa protein containing 88 amino acid residues.

Product Categories/Family for CTACK active protein

Immunology; Chemotaxis

NCBI and Uniprot Product Information

• NCBI GI #: 7674366
• NCBI GeneID: 10850
• UniProt Accession #: Q9Y4X3
• Molecular Weight: 12,618 Da
• NCBI Official Full Name: C-C motif chemokine 27
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 27
• NCBI Official Symbol: CCL27
• NCBI Official Synonym Symbols: ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27
• NCBI Protein Information: C-C motif chemokine 27; skinkine; CC chemokine ILC; IL-11 Ralpha-locus chemokine; small-inducible cytokine A27; IL-11 R-alpha-locus chemokine; cutaneous T-cell attracting chemokine; cutaneous T-cell-attracting chemokine; small inducible cytokine subfamily A (Cys-Cys), member 27
• UniProt Protein Name: C-C motif chemokine 27
• UniProt Gene Name: CCL27
• UniProt Synonym Gene Names: ILC; SCYA27; CTACK
• UniProt Entry Name: CCL27_HUMAN

NCBI Description

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL27: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; immune response; chemotaxis