TSLP active protein
Human TSLP
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Description
Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells. Ref.1 Ref.2 Ref.4
Subunit structure: Interacts with a receptor composed of CRLF2 and IL7R.
Subcellular location: Secreted Ref.1.
Tissue specificity: Expressed in a number of tissues including heart, liver and prostate. Ref.2
Induction: Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Ref.4
Research Articles on TSLP
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Product Notes
The TSLP tslp (Catalog #AAA691896) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human TSLP reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRP HCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ I NATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK QQ. It is sometimes possible for the material contained within the vial of "TSLP, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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