TIGAR active protein
Human TIGAR
NCBI and Uniprot Product Information
NCBI Description
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53. Ref.6
Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. Ref.8
Subunit structure: Monomer
By similarity.
Induction: Rapidly up-regulated by p53/TP53. Ref.6
Sequence similarities: Belongs to the phosphoglycerate mutase family.
Caution: Not expected to have any kinase activity.
Research Articles on TIGAR
Similar Products
Product Notes
The TIGAR tigar (Catalog #AAA691691) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human TIGAR reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ARFALTVVRH GETRFNKEKI IQGQGVDEPL SETGFKQAAA AGIFLN NVKF THAFSSDLMR TKQTMHGILE RSKFCKDMTV KYDSRLRERK Y GVVEGKALS ELRAMAKAAR EECPVFTPPG GETLDQVKMR GIDFFEF LCQ LILKEADQKE QFSQGSPSNC LETSLAEIFP LGKNHSSKVN SD SGIPGLAA SVLVVSHGAY MRSLFDYFLT DLKCSLPATL SRSELMSV TP NTGMSLFIIN FEEGREVKPT VQCICMNLQD HLNGLTETR. It is sometimes possible for the material contained within the vial of "TIGAR, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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