Osteoprotegerin (OPG) Active Protein | OPG active protein
Human Osteoprotegerin (OPG)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Ref.12 Ref.16
Subunit structure: Homodimer. Interacts with TNFSF10 and TNFSF11. Ref.13 Ref.16
Subcellular location: Secreted.
Tissue specificity: Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Induction: Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.
Post-translational modification: N-glycosylated. Contains sialic acid residues. Ref.16The N-terminus is blocked.
Involvement in disease: Juvenile Paget disease (JPD) [MIM:239000]: Rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17
Sequence similarities: Contains 2 death domains.Contains 4 TNFR-Cys repeats.
Research Articles on OPG
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Product Notes
The OPG tnfrsf11b (Catalog #AAA692098) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Osteoprotegerin (OPG) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCP DHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG R YLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSK APC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK. It is sometimes possible for the material contained within the vial of "Osteoprotegerin (OPG), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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