LD78-beta/CCL3L1 active protein
Human LD78-beta/CCL3L1
NCBI and Uniprot Product Information
NCBI Description
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more centromeric full-length gene. [provided by RefSeq, Apr 2010]
Uniprot Description
Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Ref.7 Ref.8
Subcellular location: Secreted.
Post-translational modification: The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.
Polymorphism: The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Research Articles on LD78-beta/CCL3L1
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Product Notes
The LD78-beta/CCL3L1 ccl3l1 (Catalog #AAA692116) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human LD78-beta/CCL3L1 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKR GRQV CADPSEEWVQ KYVSDLELSA. It is sometimes possible for the material contained within the vial of "LD78-beta/CCL3L1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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