Insulin-Like Growth Factor Binding Protein 5 Active Protein | Igfbp5 active protein

Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5, IBP5, IBP-5)

Cat. Num. AAA651053

• Gene Names: Igfbp5; IGF-BP5
• Reactivity: Human
• Purity: Highly Purified; 98% (SDS-PAGE and HPLC)
• Synonyms: Insulin-Like Growth Factor Binding Protein 5; Recombinant; Human (IGFBP5; IBP5; IBP-5); Igfbp5 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Highly Purified; 98% (SDS-PAGE and HPLC)
• Form/Format: Supplied as a lyophilized powder from 10mM Sodium Citrate solution, pH 3.0. Reconstitute in ddH2O to 0.1-1mg/ml.

• Biological Activity: The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is 0.3ug/ml, in the presence of 15ng/ml of human IGF-II.
• Endotoxin Level: 0.1ng/ug
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for at least 6 months at -20 degree C. Reconstitute with sterile ddH2O, aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for Igfbp5 active protein

Human IGF-BP5 is a 28.6kD cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6kD protein consisting of 253 amino acid residues.

Product Categories/Family for Igfbp5 active protein

Growth Factors; Cytokines; Growth Factors-IGF

NCBI and Uniprot Product Information

• NCBI GI #: 6981088
• NCBI GeneID: 25285
• NCBI Accession #: NP_036949.1
• NCBI GenBank Nucleotide #: NM_012817.1
• UniProt Accession #: P24594
• Molecular Weight: 28.6kD
• NCBI Official Full Name: insulin-like growth factor-binding protein 5
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 5
• NCBI Official Symbol: Igfbp5
• NCBI Official Synonym Symbols: IGF-BP5
• NCBI Protein Information: insulin-like growth factor-binding protein 5; IBP-5; IGFBP-5; IGF-binding protein 5
• UniProt Protein Name: Insulin-like growth factor-binding protein 5
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: Igfbp5
• UniProt Synonym Gene Names: Igfbp-5
• UniProt Entry Name: IBP5_RAT

NCBI Description

may be involved in ovarian folliculogenesis and may play a modulatory role in type I fiber-dominated muscles [RGD]

Uniprot Description

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular location: Secreted.

Tissue specificity: Mostly in kidney.

Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.