IL-36 beta (IL-1F8) active protein
Human IL-36 beta (IL-1F8)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Ref.8 Ref.9 Ref.10
Subcellular location: Secreted
Potential.
Tissue specificity: Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. Ref.9 Ref.10
Induction: By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes. Ref.8
Sequence similarities: Belongs to the IL-1 family.
Research Articles on IL-36 beta (IL-1F8)
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Product Notes
The IL-36 beta (IL-1F8) il36b (Catalog #AAA691649) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-36 beta (IL-1F8) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACR DTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD L YVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLT KER GITNNTNFYL DSVE. It is sometimes possible for the material contained within the vial of "IL-36 beta (IL-1F8), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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