IL-13 active protein
Human IL-13
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
Subunit structure: Interacts with IL13RA2.
Subcellular location: Secreted.
Involvement in disease: Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities: Belongs to the IL-4/IL-13 family.
Caution: It is uncertain whether Met-1 or Met-15 is the initiator.
Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on IL-13
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Product Notes
The IL-13 il13 (Catalog #AAA691889) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-13 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMY CAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT K IEVAQFVKD LLLHLKKLFR EGRFN. It is sometimes possible for the material contained within the vial of "IL-13, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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