IGF-BP5 active protein
Human IGF-BP5
Gene Names
IGFBP5; IBP5
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
IGF-BP5; Human IGF-BP5; Recombinant Human IGF-BP5; IGF-BP5 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQ SCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ V KIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDR RKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQ ELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKY GM KLPGMEYVDG DFQCHTFDSS NVS
Sequence Length
272
Endotoxin Level
< 0.1 ng per ug of IGF-BP5
Biological Activity
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is <= 0.3 ug/ml in the presence of 15 ng/ml of human IGF-II.
Related Product Information for IGF-BP5 active protein
IGF-BP5 is a member of the insulin-like growth factor binding protein (IGF-BP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Product Categories/Family for IGF-BP5 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28.6 kDa
NCBI Official Full Name
insulin-like growth factor-binding protein 5
NCBI Official Synonym Full Names
insulin-like growth factor binding protein 5
NCBI Official Symbol
IGFBP5
NCBI Official Synonym Symbols
IBP5
NCBI Protein Information
insulin-like growth factor-binding protein 5; IBP-5; IGFBP-5; IGF-binding protein 5
UniProt Protein Name
Insulin-like growth factor-binding protein 5
UniProt Gene Name
IGFBP5
UniProt Synonym Gene Names
IBP5; IBP-5; IGF-binding protein 5; IGFBP-5
UniProt Entry Name
IBP5_HUMAN
Uniprot Description
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular location: Secreted.
Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain.
Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.
Research Articles on IGF-BP5
Similar Products
Product Notes
The IGF-BP5 igfbp5 (Catalog #AAA692152) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IGF-BP5 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQ SCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ V KIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDR RKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQ ELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKY GM KLPGMEYVDG DFQCHTFDSS NVS. It is sometimes possible for the material contained within the vial of "IGF-BP5, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
