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Testing Data

Chemerin Active Protein | RARRES2 active protein

Human Chemerin

Gene Names
RARRES2; TIG2; HP10433
Reactivity
Species Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
Chemerin; Human Chemerin; Recombinant Human Chemerin; RARRES2 active protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Species Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
ELTEAQRRG LQVALEEFH KHPPVQWAF QETSVESAV DTPFPAGIF VRLEFKLQQ TSCRKRDWK KPECKVRPN GRKRKCLAC IKLGSEDKV LGRLVHCPI ETQVLREAE EHQETQCLR VQRAGEDPH SFYFPGQFA
Biological Activity
Determined by its ability to chemoattract human immature dendritic cells using a concentration range of 1.0-100.0 ng/ml.
Cell Type
Monocytes and Macrophages, Dendritic Cells
Preparation and Storage
At -20 degree C

Testing Data

Testing Data
Related Product Information for RARRES2 active protein
Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1). It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.
Product Categories/Family for RARRES2 active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
18,618 Da
NCBI Official Full Name
Retinoic acid receptor responder protein 2
NCBI Official Synonym Full Names
retinoic acid receptor responder (tazarotene induced) 2
NCBI Official Symbol
RARRES2
NCBI Official Synonym Symbols
TIG2; HP10433
NCBI Protein Information
retinoic acid receptor responder protein 2; chemerin; RAR-responsive protein TIG2; tazarotene-induced gene 2 protein
UniProt Protein Name
Retinoic acid receptor responder protein 2
UniProt Gene Name
RARRES2
UniProt Synonym Gene Names
TIG2
UniProt Entry Name
RARR2_HUMAN

NCBI Description

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

Uniprot Description

RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: extracellular matrix; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: positive regulation of chemotaxis; in utero embryonic development; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; retinoid metabolic process; chemotaxis; inflammatory response; embryonic gut development; regulation of lipid catabolic process

Research Articles on RARRES2

Similar Products

Product Notes

The RARRES2 rarres2 (Catalog #AAA695973) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Chemerin reacts with Species Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ELTEAQRRG LQVALEEFH KHPPVQWAF QETSVESAV DTPFPAGIF VRLEFKLQQ TSCRKRDWK KPECKVRPN GRKRKCLAC IKLGSEDKV LGRLVHCPI ETQVLREAE EHQETQCLR VQRAGEDPH SFYFPGQFA. It is sometimes possible for the material contained within the vial of "Chemerin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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