CD40 Ligand/TRAP, soluble Active Protein | CD40 Ligand/TRAP active protein
Human CD40 Ligand/TRAP, soluble
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Ref.10Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Ref.10
Subunit structure: Homotrimer.
Subcellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted.
Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.Not O-glycosylated. Ref.9
Involvement in disease: X-linked immunodeficiency with hyper-IgM 1 (HIGM1) [MIM:308230]: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on CD40 Ligand/TRAP
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Product Notes
The CD40 Ligand/TRAP cd40lg (Catalog #AAA692167) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human CD40 Ligand/TRAP, soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENG KQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE R ILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSH GTG FTSFGLLKL. It is sometimes possible for the material contained within the vial of "CD40 Ligand/TRAP, soluble, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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