Cardiotrophin-1 Active Protein | CTF1 active protein

Human Cardiotrophin-1

Cat. Num. AAA691720

• Gene Names: CTF1; CT1; CT-1
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analyses
• Synonyms: Cardiotrophin-1; Human Cardiotrophin-1; Recombinant Human Cardiotrophin-1; CTF1 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: SRREGSLEDP QTDSSVSLLP HLEAKIRQTH SLAHLLTKYA EQLLQE YVQL QGDPFGLPSF SPPRLPVAGL SAPAPSHAGL PVHERLRLDA A ALAALPPLL DAVCRRQAEL NPRAPRLLRR LEDAARQARA LGAAVEA LLA ALGAANRGPR AEPPAATASA ASATGVFPAK VLGLRVCGLY RE WLSRTEGD LGQLLPGGSA
• Sequence Length: 200

• Endotoxin Level: < 0.1 ng per g of Cardiotrophin-1
• Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was <= 1.0 ng/ml, corresponding to a specific activity of >= 1 x 106 units/mg.

Related Product Information for CTF1 active protein

CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NT-1/ BSF-3. CT-1 is a pleiotrophic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence. Recombinant Human Cardiotrophin-1 is a 21.5 kDa protein consisting of 201 amino acid residues.

Product Categories/Family for CTF1 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 216548056
• NCBI GeneID: 1489
• NCBI Accession #: NP_001136016.1
• NCBI GenBank Nucleotide #: NM_001142544.1
• UniProt Accession #: Q16619; Q5U5Y7; A8MVX4
• Molecular Weight: 21.5 kDa
• NCBI Official Full Name: cardiotrophin-1 isoform 2
• NCBI Official Synonym Full Names: cardiotrophin 1
• NCBI Official Symbol: CTF1
• NCBI Official Synonym Symbols: CT1; CT-1
• NCBI Protein Information: cardiotrophin-1; cardiophin 1
• UniProt Protein Name: Cardiotrophin-1
• Protein Family: Cardiotrophin
• UniProt Gene Name: CTF1
• UniProt Synonym Gene Names: CT-1
• UniProt Entry Name: CTF1_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular location: Secreted.

Tissue specificity: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Sequence similarities: Belongs to the IL-6 superfamily.