BMP-3 active protein
Human BMP-3
Gene Names
BMP3; BMP-3A
Reactivity
Human
Purity
>95% by SDS-PAGE & HPLC analyses
Synonyms
BMP-3; Human BMP-3; BMP3; BMP-3A; BMP-3 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
>95% by SDS-PAGE & HPLC analyses
Form/Format
Lyophilized
Sequence
MQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPM PKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD E NKNVVLKVY PNMTVESCAC R
Sequence Length
472
Biological Activity
Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
Related Product Information for BMP-3 active protein
TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
Product Categories/Family for BMP-3 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,372 Da
NCBI Official Full Name
bone morphogenetic protein 3 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 3
NCBI Official Symbol
BMP3
NCBI Official Synonym Symbols
BMP-3A
NCBI Protein Information
bone morphogenetic protein 3; BMP-3; osteogenin; bone morphogenetic protein-3; bone morphogenetic protein 3A; bone morphogenetic protein 3 (osteogenic)
UniProt Protein Name
Bone morphogenetic protein 3
UniProt Gene Name
BMP3
UniProt Synonym Gene Names
BMP3A; BMP-3; BMP-3A
UniProt Entry Name
BMP3_HUMAN
NCBI Description
BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Ref.4 Ref.6
Subunit structure: Homodimer; disulfide-linked
By similarity. Ref.8
Subcellular location: Secreted.
Tissue specificity: Expressed in adult and fetal cartilage. Ref.7
Induction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts. Ref.5
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on BMP-3
Similar Products
Product Notes
The BMP-3 bmp3 (Catalog #AAA691619) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human BMP-3 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPM PKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD E NKNVVLKVY PNMTVESCAC R. It is sometimes possible for the material contained within the vial of "BMP-3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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