Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1) Recombinant Antigen | EBNA1 antigen
EBV EBNA-1, Recombinant
Other applications have not been tested but use in such assays should not necessarily be excluded.
Contains a his-tag at the N-terminus. Molecular weight calculated from the amino acid sequence is 63 kDa.
NCBI and Uniprot Product Information
Uniprot Description
Function: Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival. Ref.8
Subunit structure: Interacts with human USP7. Interacts with human EBP2; this interaction is important for the stable segregation of EBV episomes during cell division but not for the replication of the episomes. Interacts with BGLF4; this interaction facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Ref.4 Ref.5 Ref.6 Ref.8
Subcellular location: Host nucleus Ref.3.
Sequence similarities: Belongs to the herpesviridae EBNA1 family.
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Product Notes
The Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1) Recombinant ebna1 (Catalog #AAA318777) is an Antigen produced from E. coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1) Recombinant can be used in a range of immunoassay formats including, but not limited to, Chemiluminescent Immunoassay (CLIA), Enzyme Linked Immunoassay (ELISA), Western Blot (WB). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Researchers should empirically determine the suitability of the Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1) Recombinant ebna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1) Recombinant, Antigen" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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