Vesicle-Associated Membrane Protein-Associated Protein B Active Protein | VAPB active protein

Recombinant Human Vesicle-Associated Membrane Protein-Associated Protein B

Cat. Num. AAA2556702

• Gene Names: VAPB; ALS8; VAP-B; VAMP-B
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Vesicle-Associated Membrane Protein-Associated Protein B; Recombinant Human Vesicle-Associated Membrane Protein-Associated Protein B; Vesicle-associated membrane protein-associated protein B/C; VAMP-B/VAMP-C; VAMP-associated protein B/C; VAP-B/VAP-C; VAPB active protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 99

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Ala2-Pro132
• Fusion Tag: C-6His
• Activity: Measured by its ability to bind recombinant human EphB2 in a functional ELISA.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for VAPB active protein

Protein Construction: Recombinant Human Vesicle-associated membrane protein-associated protein B is produced by our E Coli expression system and the target gene encoding Ala2-Pro132 is expressed with a 6His tag at the C-terminus.

Background: vesicle-associated membrane protein-associated protein B/C (VAPB) is presents in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. It can form homodimer, and heterodimer with VAPA. It also interacts with VAMP1, VAMP2, HCV NS5A, NS5B, ZFYVE27 and RMDN3. VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. It is involved in cellular calcium homeostasis regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 307574674
• NCBI GeneID: 9217
• NCBI Accession #: NP_001182606.1
• NCBI GenBank Nucleotide #: NM_001195677.1
• UniProt Accession #: O95292; O95293; Q9P0H0; A2A2F2
• Molecular Weight: Molecular Mass: 16.0kDa; Actual Protein Molecular Mass: 16kDa
• NCBI Official Full Name: vesicle-associated membrane protein-associated protein B/C isoform 2
• NCBI Official Synonym Full Names: VAMP associated protein B and C
• NCBI Official Symbol: VAPB
• NCBI Official Synonym Symbols: ALS8; VAP-B; VAMP-B
• NCBI Protein Information: vesicle-associated membrane protein-associated protein B/C
• UniProt Protein Name: Vesicle-associated membrane protein-associated protein B/C
• Protein Family: Virulence-associated protein
• UniProt Gene Name: VAPB
• UniProt Synonym Gene Names: VAMP-B/VAMP-C; VAMP-associated protein B/C; VAP-B/VAP-C

NCBI Description

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

Uniprot Description

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.